Gruzelier and his colleagues studied brain activity using an fMRI while subjects completed a standard cognitive exercise, called the Stroop task. The team screened subjects before the study and chose 12 that were highly susceptible to hypnosis and 12 with low susceptibility. They all completed the task in the fMRI under normal conditions and then again under hypnosis. Throughout the study, both groups were consistent in their task results, achieving similar scores regardless of their mental state. During their first task session, before hypnosis, there were no significant differences in brain activity between the groups. But under hypnosis, Gruzelier found that the highly susceptible subjects showed significantly more brain activity in the anterior cingulate gyrus than the weakly susceptible subjects. This area of the brain has been shown to respond to errors and evaluate emotional outcomes. The highly susceptible group also showed much greater brain activity on the left side of the prefrontal cortex than the weakly susceptible group. This is an area involved with higher level cognitive processing and behaviour.
In his later works, Braid reserved the term "hypnotism" for cases in which subjects entered a state of amnesia resembling sleep. For other cases, he spoke of a "mono-ideodynamic" principle to emphasise that the eye-fixation induction technique worked by narrowing the subject's attention to a single idea or train of thought ("monoideism"), which amplified the effect of the consequent "dominant idea" upon the subject's body by means of the ideo-dynamic principle.
Hypnosis is not a psychotherapeutic treatment or a form of psychotherapy, but rather a tool or procedure that helps facilitate various types of therapies and medical or psychological treatments. Only trained health care providers certified in clinical hypnosis can decide, with their patient, if hypnosis should be used along with other treatments. As with psychotherapy, the length of hypnosis treatment varies, depending on the complexity of the problem.